Wednesday, 15 July 2020 11:50

Telehealth, new technologies help testing for diseases, including COVID 19: Flinders Uni researchers

By
Flinders University Professor Youhong Tang (centre) with PhD Anh Tran Pham (left), Xinyi Zhang (Master of Engineering, Major in Biomedical Engineering), Australia-China Centre for Personal Health Technologies director Carolyn Ramsey, and Hao Fu, a graduate of Master of Engineering (Electrical and Electronic), Flinders University Flinders University Professor Youhong Tang (centre) with PhD Anh Tran Pham (left), Xinyi Zhang (Master of Engineering, Major in Biomedical Engineering), Australia-China Centre for Personal Health Technologies director Carolyn Ramsey, and Hao Fu, a graduate of Master of Engineering (Electrical and Electronic), Flinders University

In the “pandemic age” of telehealth and new technologies, remote site lab or point-of-care (POC) testing of biofluids is a potentially "rapid and non-invasive way" to test for most diseases - including COVID-19 - say scientists at South Australia’s Flinders University.

Now scientists at Flinders University have run tests on the bioprobe industry, recommending the potential of a “novel group of bioprobes with aggregation-induced emission (AIE) properties” - -called AIEgens - as being the “best way forward” to deliver accurate clinical biomarkers.

In a new journal article, the researchers recommend rapid and widespread rollout of low-cost, accurate AIE bioprobe applications which can pick up disease biomarkers in very low concentrations.

"AIE bioprobes with portable device are an exciting new method for detecting biomarkers in bodily fluids," says Flinders University Professor Youhong Tang, from the Australia-China Centre for Personal Health Technologies.

"Increasingly, these low cost and convenient technologies will help raise health services in rural areas and developing countries.

"This technique can be easily enhanced by commonly available wearable devices such as smartphone data capture and analysis, and data cloud storage," he says.

Flinders University says several applications of AIE bioprobes, such as paper-based strips and POC devices, are currently under development, and offer potential to be realised “simply by use with smartphone data capture and analysis and data cloud storage”.

“These low-cost and highly reliable AIE bioprobe applications are beneficial for both early detection of disease and chronic disease management, and may facilitate greater involvement of health care consumers in managing their own care,” the university said in a statement.

“We need to accelerate AIEgen sensor development for bodily fluids and the development of corresponding analytical and portable devices,” says Xinyi Zhang, lead author on the new Materials Chemistry Frontiers article.

“As well as rapid diagnostics, it can also facilitate greater involvement of health care consumers in managing their own care, leading to greater benefits to more people at lower cost to the system.”

The Medical Device Research Institute at Flinders University is at the forefront of developing point of care devices using this technology, says Carolyn Ramsey, director of the Australia-China Centre for Personal Health Technologies.

“As well, our partners at Nankai University in China are developing an AIEgen technology to diagnose COVID-19," she adds.

The Australia-China Centre for Personal Health Technologies is a multidisciplinary initiative in medicine, chemistry, biotechnology, engineering and digital health research led by the Flinders University Medical Device Research Institute. La Trobe University, Motherson, Nankai University, South China University of Technology and Shandong Computer Science Centre are partners in the centre.

AIEgen Luminogens for specific biomarkers – e.g. albumin, a protein produced in chronic kidney disease – works by lighting up (or fluorescing) in response to the amount of biomarker present in a person’s bodily fluid.

The new article - ‘Detection of biomarkers in body fluids using bioprobes based on aggregation-induced emission fluorogens’ (2020) - by Xinyi Zhang, Bicheng Yao, Qi Hu, Yuning Hong, Angus Wallace, Karen Reynolds, Carolyn Ramsey, Anthony Maeder, Richard Reed and Youhong Tang - has been published in the Materials Chemistry Frontiers DOI.


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Peter Dinham

Peter Dinham - retired and is a "volunteer" writer for iTWire. He is a veteran journalist and corporate communications consultant. He has worked as a journalist in all forms of media – newspapers/magazines, radio, television, press agency and now, online – including with the Canberra Times, The Examiner (Tasmania), the ABC and AAP-Reuters. As a freelance journalist he also had articles published in Australian and overseas magazines. He worked in the corporate communications/public relations sector, in-house with an airline, and as a senior executive in Australia of the world’s largest communications consultancy, Burson-Marsteller. He also ran his own communications consultancy and was a co-founder in Australia of the global photographic agency, the Image Bank (now Getty Images).

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