JUser: :_load: Unable to load user with ID: 1543
Thursday, 27 December 2007 00:55

Reprogramming cells may be as effective as stem cells

U.S. researchers have found that mature but defective skin cells in mice can be reprogrammed to eliminate sickle-cell anemia. The process may in the future be used to cure diseases in humans instead of using immature stem cells.

Rudolf Jaenisch, associated with the Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, United States), and fellow researchers inserted four regulating genes (Oct4, Sox2, Lif4, and c-Myc) into the skin of mice so that cell development was reversed, from the adult cells (called induced pluripotent stem [IPS] cells) back to immature (precursor) cells.

The technique called homologous recombination was used to remove the faulty beta-globin gene, which produces sickle-cell anemia. The disease is found in blood marrow, and is caused by this single defective gene.

The scientists then treated the new cells so that they became blood stem cells in order for new types of blood cells to be created and developed.

These precursor cells then were injected back into the bone marrow of the diseased mice. Consequently, the mice with sickle-cell anemia had all of its associated symptoms eliminated within a few days.

Like stem cells from human embryos, the Jaenisch team thinks that these reprogrammed adult cells could one day be used to cure diseases within humans.

This article is based on the Whitehead Institute for Biomedical Research article (December 6, 2007)  titled “Reprogrammed adult cells treat sickle-cell anemia in mice.”

Along with Rudolf Jaenisch, the researchers included Jacob Hanna, Marius Wernig, Styliani Markoulaki, Chiao-Wang Sun, Alexander Meissner, John P. Cassady, Caroline Beard, Tobias Brambrink, Li-Chen Wu, Tim M. Townes, Rudolf Jaenisch.

Subscribe to ITWIRE UPDATE Newsletter here

Now’s the Time for 400G Migration

The optical fibre community is anxiously awaiting the benefits that 400G capacity per wavelength will bring to existing and future fibre optic networks.

Nearly every business wants to leverage the latest in digital offerings to remain competitive in their respective markets and to provide support for fast and ever-increasing demands for data capacity. 400G is the answer.

Initial challenges are associated with supporting such project and upgrades to fulfil the promise of higher-capacity transport.

The foundation of optical networking infrastructure includes coherent optical transceivers and digital signal processing (DSP), mux/demux, ROADM, and optical amplifiers, all of which must be able to support 400G capacity.

With today’s proprietary power-hungry and high cost transceivers and DSP, how is migration to 400G networks going to be a viable option?

PacketLight's next-generation standardised solutions may be the answer. Click below to read the full article.


WEBINAR PROMOTION ON ITWIRE: It's all about webinars

These days our customers Advertising & Marketing campaigns are mainly focussed on webinars.

If you wish to promote a Webinar we recommend at least a 2 week campaign prior to your event.

The iTWire campaign will include extensive adverts on our News Site itwire.com and prominent Newsletter promotion https://www.itwire.com/itwire-update.html and Promotional News & Editorial.

This coupled with the new capabilities 5G brings opens up huge opportunities for both network operators and enterprise organisations.

We have a Webinar Business Booster Pack and other supportive programs.

We look forward to discussing your campaign goals with you.



Share News tips for the iTWire Journalists? Your tip will be anonymous




Guest Opinion

Guest Interviews

Guest Reviews

Guest Research

Guest Research & Case Studies

Channel News